• Derived from: rice
  • Pronunciation: (pan(t)-the-nal)
  • Type: Naturally-derived
  • Other names: Pro-vitamin B5

What Is DL-Panthenol?

Also known as Pro-Vitamin B5, DL-panthenol is a plant-based, white crystalline powder.[1] It is an alcohol that converts to vitamin B5 (also called pantothenic acid) on the skin via oxidization.[2]

Pantothenic acid (vitamin B) exists in all living cells and tissues and is a component of coenzyme A. It helps to release energy from carbohydrates and breaks down fatty acids (among other processes).[1]

How Is DL-Panthenol Made?

Panthenol is made by combining 3-amino-1-propanolamine with the lactone of 2,4-dihydroxy-3,3-dimethyl butyric acid. Pantothenic acid is made by condensing 3-aminopropanoic acid with the lactone of 2,4-dihydroxy-3,3-dimethyl butyric acid.[3] Panthenol can also be extracted via benzyl alcohol from an ammonium sulfate aqueous sample and then purified. Additionally, it may also separated from sugar.[4]

What Does DL-Panthenol Do?

DL-panthenol is an emollient that’s found in thousands of personal care products, including lotions, hairspray, and makeup.[1,5] In skincare, Pro Vitamin B5 is used to moisturize by attracting and trapping water.[6]

In haircare, DL-panthenol penetrates the hair shaft and conditions, smooths, and reduces static.[7]

Is DL-Panthenol Safe?

The Cosmetics Ingredient Review has deemed the ingredient safe for use in cosmetics.[1] The FDA has deemed DL-panthenol as generally recognized as safe (GRAS), and Whole Foods has determined that the ingredient is acceptable in its body care quality standards.[8,9]

Several studies have also shown the ingredient is not a skin or eye irritant or sensitizer.[10,11,12,13]

How Puracy Uses DL-Panthenol

We use DL-panthenol in our Natural Conditioner. Unlike non-biodegradable silicones, Pro-Vitamin B5 is a biodegradable substance.[14]




[1] Personal Care Council
[2] Cosmeticsinfo.org
[3] Personal Care Council
[4] Gyorgy, P., Pearson, W.N., eds., The Vitamins: Chemistry, Physiology, Pathology, Methods. (2016) Elsevier
[5] Cosmeticsinfo.org
[6] SpecialChem
[7] Salvador, A and Chisvert, A., eds. Analysis of Cosmetic Products. (2011) Elsevier Science
[8] Whole Foods Market
[9] Food and Drug Administration
[10] CTFA. (No date). Skin irritation study of a product containing 0.5 percent Panthenol. CTFA Cod No. 3-8-21
[11] CTFA (1983). Four-day minicumulative human skin irritation study with a product containing 0.5 percent Panthenol. CTFA Code No. 3-8-22
[12] Hill Top Research, Inc. (1983). Report of a human skin test of cumulative irritation. CTFA Code No. 3-8-4
[13] Ivy Research Laboratories, Inc. (1983). The determination of the contact-sensitizing potential of four materials containing 0.5 percent Panthenol by means of the maximization study. CTFA Code No. 3-8-5
[14] Medisca  

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