• Derived from: rice
  • Pronunciation: (pan(t)-the-nal)
  • Type: Naturally-derived
  • Other names: pro-vitamin B5

What Is DL-Panthenol?

DL-panthenol is a plant-based, white crystalline powder that is derived from vitamin B5.[1] It is an alcohol that converts to vitamin B5 (also called pantothenic acid) on the skin via oxidization.[2] Pantothenic acid (vitamin B) exists in all living cells and tissues and is a component of coenzyme A. It helps release energy from carbohydrates and break down fatty acids, among other things.[3] Panthenol’s ubiquity is the reason for its name (panthoten is Greek for everywhere).[4]

What Does DL-Panthenol Do in Our products?

DL-panthenol is a hair conditioner that helps keep hair soft and smooth by penetrating the hair shaft.[5] It is also an emollient that is found in thousands of personal care products, including skin care products, hairspray, and makeup.[6,7,8] It dissolves in water and is sensitive to heat.[9] 

Why Puracy Uses DL-Panthenol

We use DL-panthenol in several of our products as a hair conditioner. It is an alternative to harsh silicones, which are common in many products. The Cosmetics Ingredient Review has deemed the ingredient safe for use in cosmetics.[12] Also, the FDA has deemed DL-panthenol as generally recognized as safe (GRAS), and Whole Foods has deemed the ingredient acceptable in its body care quality standards.[13,14] Several studies have shown the ingredient is not a skin or eye irritant or sensitizer.[15,16,17,18,19,20,21]

How DL-Panthenol Is Made

Panthenol is made by combining 3-amino-1-propanolamine with the lactone of 2,4-dihydrocy-3,3-dimethyl butyric acid. Pantothenic acid is made by condensing 3-aminopropanoic acid with the lactone of 2,4-dihydroxy-3,3-dimethyl butyric acid.[10] Panthenol can also be extracted via benzyl alcohol from an ammonium sulfate aqueous sample and then purified; in addition, it can be separated from sugar.[11]



[1] Personal Care Council
[2] Cosmeticsinfo.org
[3] Personal Care Council
[4] Barel, A., et al., eds., Handbook of Cosmetic Science and Technology, Fourth Edition. (2014) CRC Press
[5] Salvador, A and Chisvert, A., eds. Analysis of Cosmetic Products. (2011) Elsevier Science
[6] Cosmeticsinfo.org
[7] Personal Care Council
[8] Personal Care Council
[9] U.S. National Library of Medicine
[10] Personal Care Council
[11] Gyorgy, P., Pearson, W.N., eds., The Vitamins: Chemistry, Physiology, Pathology, Methods. (2016) Elsevier
[12] Personal Care Council
[13] Whole Foods Market
[14] Food and Drug Administration
[15] CTFA. (No date). “Eye and skin irritation testing in rabbits with DL-Panthenol and Dexpanthenol. CTFA Code No. 3-8-2
[16] CTFA. (No date). Skin irritation study of a product containing 0.5 percent Panthenol. CTFA Cod No. 3-8-21
[17] CTFA. (1981) Rabbit ocular irritation study of mascaras containing 0.5 percent Panthenol. CTFA Code No. 3-8-18
[18] CTFA (1983). Four-day minicumulative human skin irritation study with a product containing 0.5 percent Panthenol. CTFA Code No. 3-8-22
[19] Hill Top Research, Inc. (1983). Report of a human skin test of cumulative irritation. CTFA Code No. 3-8-4
[20] Ivy Research Laboratories, Inc. (1983). The determination of the contact-sensitizing potential of four materials containing 0.5 percent Panthenol by means of the maximization study. CTFA Code No. 3-8-5
[21] CTFA. (1983). Human allergic contact sensitization testing of a product containing 0.5 percent Panthenol. CTFA Code No. 3-8-23

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