- Derived from: rice
- Pronunciation: (pan(t)-the-nal)
- Type: Naturally-derived
- Other names: Pro-vitamin B5
What Is DL-Panthenol?
Also known as Pro-Vitamin B5, DL-panthenol is a plant-based, white crystalline powder. It is an alcohol that converts to vitamin B5 (also called pantothenic acid) on the skin via oxidization.
Pantothenic acid (vitamin B) exists in all living cells and tissues and is a component of coenzyme A. It helps to release energy from carbohydrates and breaks down fatty acids (among other processes).
How Is DL-Panthenol Made?
Panthenol is made by combining 3-amino-1-propanolamine with the lactone of 2,4-dihydroxy-3,3-dimethyl butyric acid. Pantothenic acid is made by condensing 3-aminopropanoic acid with the lactone of 2,4-dihydroxy-3,3-dimethyl butyric acid. Panthenol can also be extracted via benzyl alcohol from an ammonium sulfate aqueous sample and then purified. Additionally, it may also separated from sugar.
What Does DL-Panthenol Do?
DL-panthenol is an emollient that’s found in thousands of personal care products, including lotions, hairspray, and makeup.[1,5] In skincare, Pro Vitamin B5 is used to moisturize by attracting and trapping water.
In haircare, DL-panthenol penetrates the hair shaft and conditions, smooths, and reduces static.
Is DL-Panthenol Safe?
The Cosmetics Ingredient Review has deemed the ingredient safe for use in cosmetics. The FDA has deemed DL-panthenol as generally recognized as safe (GRAS), and Whole Foods has determined that the ingredient is acceptable in its body care quality standards.[8,9]
Several studies have also shown the ingredient is not a skin or eye irritant or sensitizer.[10,11,12,13]
How Puracy Uses DL-Panthenol
We use DL-panthenol in our Natural Conditioner. Unlike non-biodegradable silicones, Pro-Vitamin B5 is a biodegradable substance.
Sources Personal Care Council
 Personal Care Council
 Gyorgy, P., Pearson, W.N., eds., The Vitamins: Chemistry, Physiology, Pathology, Methods. (2016) Elsevier
 Salvador, A and Chisvert, A., eds. Analysis of Cosmetic Products. (2011) Elsevier Science
 Whole Foods Market
 Food and Drug Administration
 CTFA. (No date). Skin irritation study of a product containing 0.5 percent Panthenol. CTFA Cod No. 3-8-21
 CTFA (1983). Four-day minicumulative human skin irritation study with a product containing 0.5 percent Panthenol. CTFA Code No. 3-8-22
 Hill Top Research, Inc. (1983). Report of a human skin test of cumulative irritation. CTFA Code No. 3-8-4
 Ivy Research Laboratories, Inc. (1983). The determination of the contact-sensitizing potential of four materials containing 0.5 percent Panthenol by means of the maximization study. CTFA Code No. 3-8-5
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